The SU2C Research Model

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OVERVIEW
Stand Up To Cancer (SU2C) is founded on the belief that there is now sufficient knowledge of the basic science of cancer and that technologies are available to allow the focused practical application and proximal translation of even more basic science knowledge to patients with cancer. Furthermore, the successful application of this knowledge will result in more rapid advances in the treatment of patients and the prevention of cancer in those individuals who are at risk. The purpose of SU2C is to establish and support a focused and intense effort to effect these advances as rapidly as possible. SU2C believes that it can benefit the most patients by accelerating the course of cancer research through raising philanthropic dollars and developing unique mechanisms to utilize these funds.

This novel approach is designed in a way that leads to the rapid funding of innovative ideas without bureaucratic delays. SU2C utilizes mechanisms to foster collaboration of the most talented and promising researchers across institutions; a team-oriented approach that promotes the sharing of information rather than inter-individual competition; and a goal-oriented focus on key problems in cancer designed with measurable milestones of progress. SU2C is committed to identifying the most promising opportunities and leveraging its fiscal and management resources to achieve a paradigm shift in clinical cancer research. SU2C is committed to transparency and high-quality science in its funding activities and believes that this can be accomplished within the framework of a truly innovative approach to support SU2C-funded research.

SU2C funds support research projects conducted by interdisciplinary, multi-institutional translational and clinical research Dream Teams and high-risk Innovative Research Grants from which ideas for new Dream Teams may arise. The funds are administered through the American Association for Cancer Research (AACR), the oldest and largest scientific organization in the world focused on every aspect of high-quality, innovative cancer research. Grants management and expert review is a nimble, rapid, flexible and transparent process carried out by a “Blue Ribbon” Scientific Advisory Committee comprised of highly accomplished clinical investigators, senior Iaboratory researchers, physician-scientists, patient advocates and an Executive Management Committee comprised of the Vice Chair (basic scientist) of the Scientific Advisory Committee, a clinical researcher, and representatives from the AACR and the Executive leadership Council of SU2C, among others.


FUNDING MECHANISMS

Dream Teams
Functions: Dream Teams are responsible for conducting collaborative, novel, groundbreaking cancer research projects that address critical problems in patient care and are designed to deliver near-term patient benefit.

Funding: Dream Teams are given sufficient resources to support the required focused, intense, goal-directed, team-oriented attack on the cancer problem, provided the Scientific Advisory Committee finds that the funds are justified and that milestones and objectives have been appropriately selected and are being satisfactorily pursued and achieved. Indirect costs charged by the institutions are capped at about 10%. The final number of Dream Teams depends on the amount of money raised.

Areas of Investigation: The foci chosen for Dream Teams will be based on both perceived opportunities for success as well as high-priority areas with critical need for rapid progress beyond current medical care. The Scientific Advisory Committee will determine the focal topics for Dream Teams, particular organ sites and other specialized research areas. Additional ideas for promising areas of investigation by Dream Teams will be solicited by the AACR from the scientific community in a parallel open process for consideration by the Scientific Advisory Committee.

Composition: Dream Teams must be translational in nature. In order to maximize creativity and innovation, they must include laboratory and clinical researchers, scientific and technical fields that are relevant to the research project senior and young investigators, and senior scientists who have not worked together in the past. Each Team consists of one or two Dream Team leaders who are experts in translational research, no more than eight Dream Team Principals, including the leaders, and at least two advocates. No Dream Team will have more than one Dream Team leader or Dream Team Principal from any given institution at the time of their initial appointment on the Team.


Innovative Research Grants
The Innovative Research Grants program provides funding for innovative, high-risk research proposals with the potential to advance SU2C’s overriding goal of improving the lives of cancer patients through the application of science to the prevention or treatment of cancer. It is the hope that ideas for new Dream Teams will emerge from these innovative research projects, and these criteria will be given the highest priority in the evaluation of these proposals. This grants program was established in the name of the late Judah Folkman, M.D., to honor him as one of the great innovators in cancer research, an outstanding teacher of young investigators and an early contributor to the SU2C mission.

This funding mechanism is not meant to replace classical funding sources; rather it will encourage novel, high-risk, high-impact proposals not usually funded by conventional peer review. Research applications are solicited annually and provide up to three years of funding of up to $250,000 per year. Each year, the AACR casts a wide net across the cancer research community to attract research proposals in both clinical and basic research. A special multidisciplinary Innovative Research Grants Committee is appointed by the Scientific Advisory Committee to review the innovative grant proposals, assess progress and make recommendations to the Scientific Advisory Committee for funding meritorious applications that are most consistent with SU2C’s goals and objectives for translational research and near-patient benefit. A high priority is given to the funding of young investigators (for example, at the Assistant Professor level) who either have expertise in, or demonstrate, clear potential for translational cancer research and who are not currently members of the funded Dream Teams. The Scientific Advisory Committee will review the report of the Innovative Grants Committee, prioritize and balance the portfolio of innovative funds, and submit its recommendations for funding to the Executive Management Committee for final action.

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There are more than 200 different types of cancer.