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SU2C Scientific Research Teams

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Zhenghe Wang, PhD

Scientific Research Team:
Zhenghe Wang, PhD

Zhenghe Wang, PhD

John Wang received his Ph.D. in Microbiology from University of Virginia in 2001 for work on the molecular mechanism of sister chromatid cohesion in yeast. He was a postdoctoral fellow with Dr. Bert Vogelstein in the Sydney Kimmel Comprehensive Cancer Center at Johns Hopkins University, where he used high throughput sequence-based mutational analysis to identify somatic mutations in human colorectal cancer. He also dissected the APC/β-catenin pathways in colorectal cells using somatic cell knockout technique. Dr. Wang joined the Department of Genetics and the Case Comprehensive Cancer Center in August, 2005.

Dr. Wang and his research group are interested in dissecting the signaling pathways controlled by phosphatases that are mutated in cancer. The role of phosphatases in tumorigenesis is less well-defined than that of kinases. However, increasing evidence suggests that phosphatases are an important component of tumor development